Lisa A. Kachnic, M.D.
Research Associate, Radiation Oncology

Email: lkachnic partners.org

Phone: 1-617-638-7070


 

Education

Institution

Degree

Year

Field of Study

Boston College,

Chestnut Hill MA

BS

1983-1987

Biology

Tufts University School of Medicine, Boston MA

MD

1987-1991

Medical Degree

Faulkner Hospital , Jamaica Plains MA

Intern

1991-1992

Internal Medicine

Massachusetts General Hospital/Harvard, Boston MA

Resident

1992-1995

Radiation Oncology

Massachusetts General Hospital/Harvard, Boston MA

Chief Resident

1995-1996

Radiation Oncology

Professional Experience

1996 - 2000

Assistant Professor, Medical College of Virginia, Dept. of Radiation Oncology

2000 - 2001

Assistant Professor of Radiology, Boston University School of Medicine

2000 - present

Lecturer, Harvard Medical School

2000 - present

Associate Radiation Oncologist, Massachusetts General Hospital, Dept. of Radiation Oncology

2000 - present

Chief, Department of Radiation Oncology, Boston Medical Center

2001 - present

Associate Professor of Radiology, Boston University School of Medicine

2005 - present

Chairperson, Cancer Care, Boston University Medical Center

2005 - present

Research Associate, Radiation Oncology, Harvard Medical School


Awards and Honors (selected)

1985

American Cancer Society Summer Research Grant, American Health Foundation, Valhalla New York

1987

Scholar of Boston College

1995-96

Chief Resident in Radiation Oncology, Massachusetts General Hospital

1996

American Society for Therapeutic Radiology and Oncology Basic Science Travel Award

2006

Guest Editor, Hematology/Oncology Clinics North America, “Radiation Medicine Update for the Practicing Oncologist, “ Volumes 1 & 2


Professional Societies and Memberships

2002 - present

Member, Study Section Breast Cancer, United States Department of Defense Medical Research

2003 - 2004

Chairperson, Study Section Breast Cancer, United States Department of Defense Medical Research

2003 - 2005

Member, Colorectal Stategic Committee, American Society of Clinical Oncology

2003 - present

Chairperson, Symptom Management Committee, Radiation Therapy Oncology Group

2004 - present

Member, Gastrointestinal Strategic Committee, Southwest Oncology Group

2004 - present

Member, American Society of Clinical Oncology

2005 - present

Member, American Association for Cancer Research

2005 - present

Member, Cancer Center Executive Committee, Boston University

2006 – present

Member, Intergroup Colorectal Task Force


Research Interests

  • To study the role of the Fanconi Anemia/BRCA pathway in determining chemo- and radiosensitivity of human cancers
  • Partial breast irradiation
  • Gastrointestinal malignancies


Publications (selected)

Original Articles

  1. Mekeel K.L., Tang W., Kachnic L.A., Luo C-M., DeFrank J.S. Powell S.N.: Inactivation of p53 Results in High Rates of Homologous Recombination. Oncogene 14: 1847-1857, 1997.
  2. Kachnic L.A., Wu B., Wunsch H., Mekeel K.L., DeFrank J.S., Tang W., Powell S.N.: The Ability of p53 to Activate Downstream Genes p21 (WAF1/cip1) and MDM2, and Cell Cycle Arrest following DNA Damage is Delayed and Attenuated in scid cells Deficient in the DNA Dependent Protein Kinase. J Biol Chem 274: 13111-13117, 1999.
  3. Kachnic L. A., Powell S. N.: Can ICAM Modulation Prevent Lung Injury From Ionizing Radiation? JNCI 94: 704-705, 2002.
  4. Chawla A. K., Kachnic L. A., Taghian A. G., Zapton D. T., Powell S.: Radiation and Breast Reconstruction: Complications and Cosmesis with TRAM versus Tissue Expander/Implant. Int J Radiat Oncol Biol Phys 54: 520-526, 2002.
  5. Coen JJ, Taghian AG, Kachnic L.A, Assaad SI, and Powell SN. Risk of Lymphedema After Regional Nodal Irradiation With Breast Conservation Therapy. Int J Radiat Oncol Biol Phys 55: 1209-1215, 2003.
  6. Lawenda, B.D., Taghian, A.G., Kachnic, L.A., Hamdi, H., Smith, B.L., Gadd, M.A., Mauceri, T. and Powell, S.N. A Dose-Volume Analysis of Radiation Therapy for T1N0 Invasive Breast Cancer treated by Local Excision and
    Partial Breast Irradiation by Low-Dose Rate Interstitial Implant. Int J. Radiat. Oncol. Biol. Phys 56: 671-680, 2003.
  7. Chawla AK , Kachnic L.A, Clark JW, Willett CG. Combined modality therapy for rectal and colon cancer. Semin Oncol. Aug; 30(4 Suppl 9): 101-12, 2003.
  8. Kachnic L.A, Shih HA, Willett CG. Advances in combined radiation therapy for the management of rectal cancer. Expert Rev Anticancer Ther. Aug; 3: 471-83, 2003.
  9. Powell, S.N. and Kachnic, L.A. The Roles of BRCA 1 and BRCA 2 in Homologous Recombination, DNA Replication Fidelity and the Cellular Response to Ionizing Radiation. Oncogene. 22:5784-90, 2003.
  10. Suntharalingam, M., Moughan, J., Coia, L., Krasna, M., Kachnic, L. A., Haller, D., Willett, C., John, M., Minsky, D., Owen, J.: The National Practice for Patients Receiving Radiation Therapy for Carcinoma of the Esophagus: Results of the 1996-1999 Patterns of Care Study. Int J Radiat Oncol Biol Phys 56: 981-987, 2003.
  11. Yock T. I., Taghian A. G., Kachnic L. A., Coen J. J., Assaad S. I., Powell S. N.: The Effect of Delaying Radiation Therapy for Systematic Chemotherapy on Local Control in Breast Cancer. Cancer. Breast Cancer Res Treat. 84: 161-71, 2004.
  12. Feng Z, Kachnic L. A., Zhang J, Powell SN, Xia F.: DNA Damage Induces p53-dependent BCRA1 Nuclear Export. J Biol Chem. 279: 28574-84, 2004.
  13. Ceilley E, Jagsi R, Goldberg S, Kachnic L. A., Powell S, Taghian A.: The Management of Ductal Carcinoma in Situ in North America and Europe. Cancer 101: 1958-67, 2004.
  14. Frechette E, Buck DA, Kaplan BJ, Chung TD, Shaw JE, Kachnic LA, Neifeld JP: Esophageal Cancer: Outomes of Surgery, Neoadjuvant Chemotherapy, and Three-dimensional Conformal Radiotherapy. J Surg Oncol 87: 68-74, 2004.
  15. Suntharalingam M, Moughan J, Coia LR, Krasna MJ, Kachnic L, Haller D, Willett CG, John MJ, Minsky BD, Owen JB: Oucome Results of the 1996-1999 Patterns of Care Survey of the National Practice for Patients Receiving Radiation Therapy for Carcinoma of the Esophagus. J Clin Oncol. 23: 2325-2331, 2005.
  16. Lai LL, Fuller CD, Kachnic LA and Thomas CR, Jr.: Can pelvic radiotherapy be omitted in selected patients with rectal cancer? Semin Oncol. 2006 11:70-4.
  17. Daly BD, Fernando HC, Ketchedjian A, Dipetrillo TA, Kachnic LA, Morelli DM, Shemin RJ: Pneumonectomy after High-dose Radiation and Concurrent Chemotherapy for Nonsmall Cell Lung Cancer. Ann Thorac Surg 2006 Jul;82(1):227-31.
  18. Blackstock AW, Mornex F, Partensky C, Descos L, Case LD, Melin SA, Levine EA, Mishra G, Limentani SA, Kachnic LA, Tepper JE: Adjuvant Gemcitabine and Concurrent Radiation for Patients with Resected Pancreatic Cancer: A Phase II Study. Br J Cancer 2006 Aug 7;95(3):260-5.
  19. Taghian AG, Kozak KR, Doppke KP, Smith BL, Gadd M, Specht M, Hughes K, Braaten K, Kachnic LA, Recht A, Powell SN: Initial Dosimetric Experience Using Simple Three-Dimensional Conformal External-beam Accelerated Partial-breast Irradiation. Int J Radiat Oncol Biol Phys 2006 64: 1092-1099.
  20. Hong TS and Kachnic LA: Preoperative Chemoradiation in the Management of Localized Rectal Cancer: The New Standard. GCR-0004-06. Accepted for publication in Gastrointestinal Cancer Research, January 2007.

 

Invited Editorials / Reviews / Book Chapters

  1. Hong TS and Kachnic LA: Preoperative Chemoradiation in the Management of Localized Rectal Cancer: The New Standard. GCR-0004-06. Accepted for publication in Gastrointestinal Cancer Research, January 2007. Manuscript.
  2. Kachnic LA. : Should preoperative or postoperative therapy be administered in the management of rectal cancer? Semin Oncol. 2006 11: 64-9. Manuscript.
  3. Siddiqui F, Kachnic LA, Movsas B: Quality of Life Outcomes in Oncology. Hematol Oncol Clin North Am. 2006 Apr 20;(2): 165-185. Manuscript.
  4. Hung AY, Canning CA, Patel KM, Holland JM, Kachnic LA: Radiation Therapy for Gastrointestinal Cancer. Hematol Oncol Clin North Am 2006 Apr20;(2): 287-320. Manuscript.
  5. Kachnic LA, Thomas CR: Radiation Medicine Update for the Practicing Oncologist,Volumes 1 & 2. Hematol Oncol Clin North Am 2006 Feb & Apr. Guest Editor.
  6. Small W Jr, Kachnic L: Postradiotherapy Pelvic Fractures: Cause for Concern or Opportunity for Future Research? JAMA 2005 Nov 23; 294(20):2635-7. Editorial.
  7. Kachnic LA and Berk L: Palliative Single Fraction Radiation for Painful Bone Metastases: How Much More Evidence Is Needed? J Natl Cancer Inst 2005 June 1; 97(11). Editorial.

 

 

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