• To study the role of the Fanconi Anemia/BRCA pathway in determining chemo- and radiosensitivity of human cancers
• Partial breast irradiation
• Gastrointestinal malignancies

Original Articles

Mekeel K.L., Tang W., Kachnic L.A., Luo C-M., DeFrank J.S. Powell S.N.: Inactivation of p53 Results in High Rates of Homologous Recombination. Oncogene 14: 1847-1857, 1997.
Kachnic L.A., Wu B., Wunsch H., Mekeel K.L., DeFrank J.S., Tang W., Powell S.N.: The Ability of p53 to Activate Downstream Genes p21 (WAF1/cip1) and MDM2, and Cell Cycle Arrest following DNA Damage is Delayed and Attenuated in scid cells Deficient in the DNA Dependent Protein Kinase. J Biol Chem 274: 13111-13117, 1999.
Kachnic L. A., Powell S. N.: Can ICAM Modulation Prevent Lung Injury From Ionizing Radiation? JNCI 94: 704-705, 2002.
Chawla A. K., Kachnic L. A., Taghian A. G., Zapton D. T., Powell S.: Radiation and Breast Reconstruction: Complications and Cosmesis with TRAM versus Tissue Expander/Implant. Int J Radiat Oncol Biol Phys 54: 520-526, 2002.
Coen JJ, Taghian AG, Kachnic L.A, Assaad SI, and Powell SN. Risk of Lymphedema After Regional Nodal Irradiation With Breast Conservation Therapy. Int J Radiat Oncol Biol Phys 55: 1209-1215, 2003.
Lawenda, B.D., Taghian, A.G., Kachnic, L.A., Hamdi, H., Smith, B.L., Gadd, M.A., Mauceri, T. and Powell, S.N. A Dose-Volume Analysis of Radiation Therapy for T1N0 Invasive Breast Cancer treated by Local Excision and
Partial Breast Irradiation by Low-Dose Rate Interstitial Implant. Int J. Radiat. Oncol. Biol. Phys 56: 671-680, 2003.
Chawla AK , Kachnic L.A, Clark JW, Willett CG. Combined modality therapy for rectal and colon cancer. Semin Oncol. Aug; 30(4 Suppl 9): 101-12, 2003.
Kachnic L.A, Shih HA, Willett CG. Advances in combined radiation therapy for the management of rectal cancer. Expert Rev Anticancer Ther. Aug; 3: 471-83, 2003.
Powell, S.N. and Kachnic, L.A. The Roles of BRCA 1 and BRCA 2 in Homologous Recombination, DNA Replication Fidelity and the Cellular Response to Ionizing Radiation. Oncogene. 22:5784-90, 2003.
Suntharalingam, M., Moughan, J., Coia, L., Krasna, M., Kachnic, L. A., Haller, D., Willett, C., John, M., Minsky, D., Owen, J.: The National Practice for Patients Receiving Radiation Therapy for Carcinoma of the Esophagus: Results of the 1996-1999 Patterns of Care Study. Int J Radiat Oncol Biol Phys 56: 981-987, 2003.
Yock T. I., Taghian A. G., Kachnic L. A., Coen J. J., Assaad S. I., Powell S. N.: The Effect of Delaying Radiation Therapy for Systematic Chemotherapy on Local Control in Breast Cancer. Cancer. Breast Cancer Res Treat. 84: 161-71, 2004.
Feng Z, Kachnic L. A., Zhang J, Powell SN, Xia F.: DNA Damage Induces p53-dependent BCRA1 Nuclear Export. J Biol Chem. 279: 28574-84, 2004.
Ceilley E, Jagsi R, Goldberg S, Kachnic L. A., Powell S, Taghian A.: The Management of Ductal Carcinoma in Situ in North America and Europe. Cancer 101: 1958-67, 2004.
Frechette E, Buck DA, Kaplan BJ, Chung TD, Shaw JE, Kachnic LA, Neifeld JP: Esophageal Cancer: Outomes of Surgery, Neoadjuvant Chemotherapy, and Three-dimensional Conformal Radiotherapy. J Surg Oncol 87: 68-74, 2004.
Suntharalingam M, Moughan J, Coia LR, Krasna MJ, Kachnic L, Haller D, Willett CG, John MJ, Minsky BD, Owen JB: Oucome Results of the 1996-1999 Patterns of Care Survey of the National Practice for Patients Receiving Radiation Therapy for Carcinoma of the Esophagus. J Clin Oncol. 23: 2325-2331, 2005.
Lai LL, Fuller CD, Kachnic LA and Thomas CR, Jr.: Can pelvic radiotherapy be omitted in selected patients with rectal cancer? Semin Oncol. 2006 11:70-4.
Daly BD, Fernando HC, Ketchedjian A, Dipetrillo TA, Kachnic LA, Morelli DM, Shemin RJ: Pneumonectomy after High-dose Radiation and Concurrent Chemotherapy for Nonsmall Cell Lung Cancer. Ann Thorac Surg 2006 Jul;82(1):227-31.
Blackstock AW, Mornex F, Partensky C, Descos L, Case LD, Melin SA, Levine EA, Mishra G, Limentani SA, Kachnic LA, Tepper JE: Adjuvant Gemcitabine and Concurrent Radiation for Patients with Resected Pancreatic Cancer: A Phase II Study. Br J Cancer 2006 Aug 7;95(3):260-5.
Taghian AG, Kozak KR, Doppke KP, Smith BL, Gadd M, Specht M, Hughes K, Braaten K, Kachnic LA, Recht A, Powell SN: Initial Dosimetric Experience Using Simple Three-Dimensional Conformal External-beam Accelerated Partial-breast Irradiation. Int J Radiat Oncol Biol Phys 2006 64: 1092-1099.
Hong TS and Kachnic LA: Preoperative Chemoradiation in the Management of Localized Rectal Cancer: The New Standard. GCR-0004-06. Accepted for publication in Gastrointestinal Cancer Research, January 2007.

Invited Editorials / Reviews / Book Chapters

Hong TS and Kachnic LA: Preoperative Chemoradiation in the Management of Localized Rectal Cancer: The New Standard. GCR-0004-06. Accepted for publication in Gastrointestinal Cancer Research, January 2007. Manuscript.
Kachnic LA. : Should preoperative or postoperative therapy be administered in the management of rectal cancer? Semin Oncol. 2006 11: 64-9. Manuscript.
Siddiqui F, Kachnic LA, Movsas B: Quality of Life Outcomes in Oncology. Hematol Oncol Clin North Am. 2006 Apr 20;(2): 165-185. Manuscript.
Hung AY, Canning CA, Patel KM, Holland JM, Kachnic LA: Radiation Therapy for Gastrointestinal Cancer. Hematol Oncol Clin North Am 2006 Apr20;(2): 287-320. Manuscript.
Kachnic LA, Thomas CR: Radiation Medicine Update for the Practicing Oncologist,Volumes 1 & 2. Hematol Oncol Clin North Am 2006 Feb & Apr. Guest Editor.
Small W Jr, Kachnic L: Postradiotherapy Pelvic Fractures: Cause for Concern or Opportunity for Future Research? JAMA 2005 Nov 23; 294(20):2635-7. Editorial.
Kachnic LA and Berk L: Palliative Single Fraction Radiation for Painful Bone Metastases: How Much More Evidence Is Needed? J Natl Cancer Inst 2005 June 1; 97(11). Editorial.